Purpose: The insidious onset and variety of clinical symptoms of cervical myelopathy (CM) pose a big challenge to clinician for early diagnosis and precise prognostication. The gross morphological and signal changes in T2-weighted magnetic resonance images (MRI) did not necessarily correlate with the severity of chronic compressive injuries of spinal cord. In the present study, we aimed to employ a relatively novel index in diffusion MR imaging directional entropy (DE) to investigate the potential pathogenic levels in CM patients.